منابع مشابه
Centripetal modules and ancient introns.
We have created an algorithm which instantiates the centripetal definition of modules, compact regions of protein structure, as introduced by Go and Nosaka (M. Go and M. Nosaka, 1987. Protein architecture and the origin of introns. Cold Spring Harbor Symp. Quant. Bio. 52, 915-924). That definition seeks the minima of a function that sums the squares of C-alpha carbon distances over a window aro...
متن کاملIntron distribution difference for 276 ancient and 131 modern genes suggests the existence of ancient introns.
o introns delineate elements of protein tertiary structure? This issue is crucial to the debate about the role and origin of introns. We present an analysis of the full set of proteins with known three-dimensional structures that have homologs with intron positions recorded in GenBank. A computer program was generated that maps on a reference sequence the positions of all introns in homologous ...
متن کاملIntrons
type description (DTD). The DTD is the classification system that defines the different types of information pieces in any document. In each DTD the key XML 'tags', or descriptors, are described. Any one DTD can be used as the rule-set for any number of XML documents. This is the aspect of XML that is of most importance to scientists, because of its potential to improve dramatically the ability...
متن کاملToward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins.
We present evidence that a well defined subset of intron positions shows a non-random distribution in ancient genes. We analyze a database of ancient conserved regions drawn from GenBank 101 to retest two predictions of the theory that the first genes were constructed by exon shuffling. These predictions are that there should be an excess of symmetric exons (and sets of exons) flanked by intron...
متن کاملIntrons: The Functional Benefits of Introns in Genomes
The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns. Second, the amount of total introns varies in different species. Third, the length and number of introns vary in different genes, even within the same spec...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20011113-01